Estudio de los determinantes genéticos de resistencias a biocidas y su papel en la resistencia cruzada con antibióticos en bacterias de origen alimentario

Abstract

Our objective was to investigate the incidence of antibiotic and biocide resistance in food-borne bacteria. For this, such resistance was analyzed by culture dependent and independent methods throughout the chain of meat production, also phenotypic and genotypic resistance was evaluated in both pathogens microbial groups such as Pseudomonas sp. and Enterococcus sp. Our results indicated a high resistance to antibiotics commonly used in clinical treatments and to biocides frequently used in the food industry, also we have revealed the molecular mechanisms involved in this resistance (specific genes and efflux pumps) . In addition, we have determined by means of statistical studies the interconnection between both antimicrobials which was reflected by a cross-resistance between sorne biocides and antibiotics thus suggesting that such measures to be taken to prevent the spread of resistance genes throughout the food chain.