Implicación del hidroxitirosol, tirosol y escualeno en la prevención del cáncer de mama humanoevaluación en modelos celulares in vitro

  1. Fernando Warleta Arias
Supervised by:
  1. José Juan Gaforio Martínez Director

Defence university: Universidad de Jaén

Fecha de defensa: 29 January 2016

  1. María del Carmen Ramírez Tortosa Chair
  2. María Luisa del Moral Leal Secretary
  3. Gabriel Beltrán Maza Committee member

Type: Thesis

Teseo: 424440 DIALNET lock_openRUJA editor


Reactive Oxygen Species (ROS) cause molecular oxidative damage including DNA oxidative damage being responsible of tumorigenesis. Several studies have related Virgin Olive Oil (VOO) ingestion, usual in Mediterranean diet, to a low incidence of cancers, including breast cancer. VOO may act reducing ROS levels. Hydroxytyrosol, tyrosol and squalene, three of the main minor compounds present in VOO, may participate in the breast cancer prevention attributed to VOO. The experiments developed in this thesis are aimed to study the effect of these compounds in human breast MCF7 and MDA-MB-231 cancer cells compared with the effect in human breast epithelial MCF10A cells. Our results show a different action of hydroxytyrosol, tyrosol and squalene between tumor and no tumor cells: The three compounds fail to exert modulation in breast tumor cells, The three compounds act as efficient free radical scavenger in epithelial breast cells, preventing tumorigenesis.