Correlatos genéticos y conductuales de la frustración. Estudios con ratas romanas de alta (RHA-I) y baja (RLA-I) evitación

  1. Sabariego Almazán, Marta
Supervised by:
  1. Ignacio Morón Henche Director
  2. Carmen Torres Bares Director

Defence university: Universidad de Jaén

Fecha de defensa: 18 September 2013

  1. Mauricio Papini Chair
  2. Francisco José Esteban Ruiz Secretary
  3. M. Ángeles Ballesteros Duperón Committee member

Type: Thesis

Teseo: 363794 DIALNET lock_openRUJA editor


Reward loss experiences are among the main sources of emotional stress that humans have to face throughout their lives (Kamenetzky et al., 2009). In the animal laboratory, it has been repeatedly shown that the unexpected omission or devaluation of a reinforcer triggers a physiological, cognitive, and behavioral state called frustration (Amsel, 1992). the present dissertation analyze the behavioral and genetic correlates of frustration in two strains of animals selected on the basis of their extreme differences in active avoidance learning: The inbred Roman High-­‐ (RHA-­‐I) and Roman Low-­‐ Avoidance (RLA-­‐I) rats. I first extended the behavioral phenotyping of Roman rats to a frustrating situation: identified some genes whose differential brain expression could underlie strain differences observed in frustrative situation as the instrumental successive negative contrast paradigm SNCi.