Estudio de las propiedades antitumorales, antioxidantes y antiinflamatorias de los principales triterpenos del Aceite de Oliva Virgen utilizando modelos experimentales celulares de mama

Abstract

Oleanolic acid, maslinic acid, uvaol and erytrodiol conform a triterpenic group of compounds, which could be found in leaf, olives and virgin olive oil (VOO). These compounds have antitumoral properties in different cancers but until now, there is not any study about the antitumor or preventive capacities of these compounds in breast cancer. Among the risk factors described for developing breast cancer are included diet and life style. These compounds are part of the main source of fat of Mediterranean diet, and interestingly, Mediterranean countries have lower incidence and mortality of breast cancer than others. In this thesis, antitumoral, antioxidant and anti-inflammatory effects of these VOO triterpenes are studied in an invasive breast cancer cell line (MDA-MB-231) and in a breast epithelial cell line (MCF10A).