Consecuencias de la uninefrectomía sobre la función cardiovascular y renal en ratasutilidad de las aminopeptidasas urinarias como marcadores de disfunción renal

Résumé

The effects of uninephrectomy in 6-week-old male and female rats on blood pressure, renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery were investigated, and urinary enzymatic activities of glutamil, alanil, cistinil and aspartil aminopeptidase as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats were analyzed. Long-term uninephrectomy increased the blood pressure, creatinine, proteinuria, pathological signs of renal injury, and salt sensitivity. Earlier blood pressure elevation was observed and morphological lesions were more severe in male than in female uninephrectomized rats. Aminopeptidase enzymatic activities are early and predictive urinary biomarkers of the renal dysfunction induced by cisplatin.