Consecuencias de la uninefrectomía sobre la función cardiovascular y renal en ratasutilidad de las aminopeptidasas urinarias como marcadores de disfunción renal
- Quesada Miñarro, Andrés
- José Félix Vargas Palomares Doktorvater/Doktormutter
- Rosemary Wangensteen Fuentes Doktormutter
Universität der Verteidigung: Universidad de Jaén
Fecha de defensa: 26 von Februar von 2014
- Juan Manuel Duarte Pérez Präsident/in
- Juan Manuel Ramirez Sanchez Sekretär/in
- Antonio Osuna Ortega Vocal
Art: Dissertation
Zusammenfassung
The effects of uninephrectomy in 6-week-old male and female rats on blood pressure, renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery were investigated, and urinary enzymatic activities of glutamil, alanil, cistinil and aspartil aminopeptidase as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats were analyzed. Long-term uninephrectomy increased the blood pressure, creatinine, proteinuria, pathological signs of renal injury, and salt sensitivity. Earlier blood pressure elevation was observed and morphological lesions were more severe in male than in female uninephrectomized rats. Aminopeptidase enzymatic activities are early and predictive urinary biomarkers of the renal dysfunction induced by cisplatin.