Síntesis de sistemas moleculares híbridos integrando fragmentos azólicos con reconocidos farmacóforos inspirados en compuestos naturales

Abstract

This project is based on the use of nitrogenated heterocyclic systems of the azole type, presented as hybrids with pyrimidines and isocoumarins. The selection of these nuclei was grounded in their recognized bioactivity and synthetic versatility for generating new molecules. Two synthetic strategies were implemented: the first utilized 2-amino-4,6-dimethoxypyrimidine, acknowledged for its 2-aminopyrimidine fragment with pharmacophoric properties. Despite successfully synthesizing pyrimidine-imidazole systems, they did not demonstrate promising bioactivity in evaluated cancer cell lines. The second strategy drew inspiration from nuclei present in natural products, generating isocoumarin-azole systems. Both strategies yielded hybrid compounds, contributing to the diversification of starting nuclei. The project was conducted within the Research Group on Compounds of Biological Interest (GICIB) at UJA, in the research line "Search for Bioactive Compounds: Nitrogenated Heterocyclic Derivatives.