Puntos de control inmunitariorecientes avances y potenciales biomarcadores en la enfermedad celíaca

Abstract

In the present PhD project, we addressed the study of different immunomodulatory proteins in celiac disease (CD) through their molecular and celular characterisation. The PD-1: PD-L1/PD-L2, CD200:CD200R pathways and the elafin protein were selected from among the molecules considered immune checkpoints for their relevant role in promoting immune tolerance and mediating autoimmunity. The results provided evidence that in CD, immune checkpoints are compromised or dysregulated, their expression is altered and their levels vary with the pathological state of the disease, contributing to inflammation and the autoimmune process. These findings made it possible to link the key role of immune regulatory proteins to CD. Thus, this knowledge will help in the development of therapies aimed at restoring immune balance in CD.