Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals

  1. Reyes del Paso, Gustavo A. 1
  2. Montoro, Casandra I. 1
  3. Jennings, J. Richard 2
  4. Duschek, Stefan 3
  1. 1 Department of Psychology, University of Jaén
  2. 2 Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, USA
  3. 3 UMIT TIROL - University for Health Sciences and Technology, Hall in Tirol, Austria
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Revista:
The Journal of Physiological Sciences

ISSN: 1880-6562

Año de publicación: 2023

Volumen: 73

Número: 1

Tipo: Artículo

DOI: 10.1186/S12576-023-00871-7 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: The Journal of Physiological Sciences

Objetivos de desarrollo sostenible

Resumen

This study investigated effects of experimental baroreceptor stimulation on bilateral blood flow velocities in the anterior and middle cerebral arteries (ACA and MCA) using functional transcranial Doppler sonography. Carotid baroreceptors were stimulated by neck suction in 33 healthy participants. Therefore, negative pressure (− 50 mmHg) was applied; neck pressure (+ 10 mmHg) was used as a control condition. Heart rate (HR) and blood pressure (BP) were also continuously recorded. Neck suction led to reductions in bilateral ACA and MCA blood flow velocities, which accompanied the expected HR and BP decreases; HR and BP decreases correlated positively with the ACA flow velocity decline. The observations suggest reduction of blood flow in the perfusion territories of the ACA and MCA during baroreceptor stimulation. Baroreceptor-related HR and BP decreases may contribute to the cerebral blood flow decline. The findings underline the interaction between peripheral and cerebral hemodynamic regulation in autoregulatory control of cerebral perfusion.

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