Epidemiological Profile of Patients with Vulvovaginal Candidiasis from a Sexually Transmitted Infection Clinic in Southern Spain

  1. Martínez-García, Encarnación 14
  2. Martínez-Martínez, Juan Carlos 3
  3. Martín-Salvador, Adelina 1
  4. González-García, Alberto 1
  5. Pérez-Morente, María Ángeles 2
  6. Álvarez-Serrano, María Adelaida 5
  7. García-García, Inmaculada 1
  1. 1 Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain
  2. 2 Department of Nursing, Faculty of Health Sciences, University of Jaén, 23071 Jaen, Spain
  3. 3 Virgen de las Nieves University Hospital, Andalusian Health Service, 18014 Granada, Spain
  4. 4 Guadix High Resolution Hospital, Andalusian Health Service, 18500 Granada, Spain
  5. 5 Department of Nursing, Faculty of Health Sciences of Ceuta, University of Granada, 51001 Ceuta, Spain
Revista:
Pathogens

ISSN: 2076-0817

Año de publicación: 2023

Volumen: 12

Número: 6

Páginas: 756

Tipo: Artículo

DOI: 10.3390/PATHOGENS12060756 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Pathogens

Resumen

Epidemiological data on women suffering from vulvovaginal candidiasis and its recurrence are outdated and vague. The aim of this study was to identify the prevalence of women diagnosed with vulvovaginal candidiasis, as well as the epidemiological profile and associated risk factors in the province of Granada (Spain). Data from the Centre for Sexually Transmitted Infections of the Granada province between 2000 and 2018 (N = 438) were used in this study. Associations between sociodemographic and sexual behaviour variables with vulvovaginal candidiasis were analysed using the Chi-square test and bivariate logistic regression. The prevalence of candidiasis was 14.6%. The sociodemographic profile corresponded to a woman aged 25.14 ± 4.8 years on average, who is of Spanish nationality (60.9%), a student (55.7%), in non-active employment (59.7%), with a higher education (56.7%), single (93.5%), and under 30 years of age (79.7%). Variables associated with this diagnosis were the absence of oro-genital contact (OR = 1.99; 95% CI = 0.25–0.74), having a regular partner (OR = 1.99; 95% CI = 1.05–3.75), and age of sexual debut, with the probability increasing by 12% (95% CI = 1.00–1.24) with each year. In this context, vulvovaginal candidiasis infection is common, and its epidemiological profile is contradictory, so our results do not suggest a relevant role of sexual risk behaviours in the diagnosis. Further research is needed to improve the estimates and factors associated with this infection.

Información de financiación

Financiadores

  • Universidad de Granada/CBUA
    • 2022/09

Referencias bibliográficas

  • Sobel, (2007), Lancet, 369, pp. 1961, 10.1016/S0140-6736(07)60917-9
  • Denning, (2018), Lancet Infect. Dis., 18, pp. e339, 10.1016/S1473-3099(18)30103-8
  • Benedict, K., Lyman, M., and Jackson, B.R. (2022). Possible misdiagnosis, inappropriate empiric treatment, and opportunities for increased diagnostic testing for patients with vulvovaginal candidiasis—United States, 2018. PLoS ONE, 17.
  • Rathod, S.D., and Buffler, P.A. (2014). Highly-cited estimates of the cumulative incidence and recurrence of vulvovaginal candidiasis are inadequately documented. BMC Women Health, 14.
  • Donders, (2022), Front. Cell. Infect. Microbiol., 12, pp. 934353, 10.3389/fcimb.2022.934353
  • Sherrard, (2018), Int. J. STD AIDS, 29, pp. 1258, 10.1177/0956462418785451
  • Sustr, V., Foessleitner, P., Kiss, H., and Farr, A. (2020). Vulvovaginal Candidosis: Current Concepts, Challenges and Perspectives. J. Fungi, 6.
  • Willems, H.M.E., Ahmed, S.S., Liu, J., Xu, Z., and Peters, B.M. (2020). Vulvovaginal Candidiasis: A Current Understanding and Burning Questions. J. Fungi, 6.
  • Rylander, (2004), Sex Transm. Infect., 80, pp. 54, 10.1136/sti.2003.004192
  • Apalata, (2014), Ann. Med. Health Sci. Res., 4, pp. 410, 10.4103/2141-9248.133470
  • Ray, (2011), Cochrane Database Syst. Rev., 8, pp. CD008739
  • Simon, (2006), Lancet, 368, pp. 489, 10.1016/S0140-6736(06)69157-5
  • Neal, (2022), SAGE Open Med., 10, pp. 205031212211152, 10.1177/20503121221115201
  • Cooke, (2022), Cochrane Database Syst. Rev., 1, pp. CD009151
  • Sobel, (2018), Expert Opin. Pharmacother., 19, pp. 971, 10.1080/14656566.2018.1476490
  • Amouri, (2011), Mycoses, 54, pp. e499, 10.1111/j.1439-0507.2010.01965.x
  • Foxman, (2013), J. Low. Genit. Tract Dis., 17, pp. 340, 10.1097/LGT.0b013e318273e8cf
  • Yano, J., Sobel, J.D., Nyirjesy, P., Sobel, R., Williams, V.L., Yu, Q., Noverr, M.C., and Fidel, P.L. (2019). Current patient perspectives of vulvovaginal candidiasis: Incidence, symptoms, management and post-treatment outcomes. BMC Womens Health, 19.
  • Hospital Universitario Virgen de las Nieves (2020). Memoria Anual 2020, Hospital Universitario Virgen de las Nieves. Available online: https://www.comunidad.madrid/hospital/lapaz/nosotros/memorias-0.
  • Instituto Nacional de Estadística (2023, May 22). Resident Population by Date, Sex, Age Group and Nationality, Available online: https://ine.es/jaxiT3/Tabla.htm?t=9689.
  • Pérez-Morente, M.A., Sánchez-Ocón, M.T., Martínez-García, E., Martín-Salvador, A., Hueso-Montoro, C., and García-García, I. (2019). Differences in Sexually Transmitted Infections between the Precrisis Period (2000–2007) and the Crisis Period (2008–2014) in Granada, Spain. J. Clin. Med., 8.
  • (2020), Rev. Española Quim., 33, pp. 187, 10.37201/req/099.2019
  • (2013), Clin. Investig. Ginecol. Obstet., 40, pp. 242
  • (2019), Clin. Investig. Ginecol. Obstet., 46, pp. 154
  • (2000), Atención Primaria, 25, pp. 103, 10.1016/S0212-6567(00)78471-X
  • Maraki, (2019), Mycoses, 62, pp. 692, 10.1111/myc.12946
  • Grigoriou, (2006), Eur. J. Obstet. Gynecol. Reprod. Biol., 126, pp. 121, 10.1016/j.ejogrb.2005.09.015
  • Intra, (2022), J. Med. Mycol., 32, pp. 101278, 10.1016/j.mycmed.2022.101278
  • Tibaldi, (2009), Clin. Microbiol. Infect., 15, pp. 670, 10.1111/j.1469-0691.2009.02842.x
  • Benedict, K., Singleton, A.L., Jackson, B.R., and Molinari, N.A.M. (2022). Survey of incidence, lifetime prevalence, and treatment of self-reported vulvovaginal candidiasis, United States, 2020. BMC Womens Health, 22.
  • Mushi, (2022), Med. Mycol., 60, pp. myac037, 10.1093/mmy/myac037
  • Blostein, (2017), Ann. Epidemiol., 27, pp. 575, 10.1016/j.annepidem.2017.08.010
  • Brandolt, (2017), Braz. J. Microbiol., 48, pp. 145, 10.1016/j.bjm.2016.09.006
  • Jacob, (2018), Curr. Med. Mycol., 4, pp. 6, 10.18502/cmm.4.1.27
  • Drell, T., Lillsaar, T., Tummeleht, L., Simm, J., Aaspõllu, A., Väin, E., Saarma, I., Salumets, A., Donders, G.G., and Metsis, M. (2013). Characterization of the Vaginal Micro- and Mycobiome in Asymptomatic Reproductive-Age Estonian Women. PLoS ONE, 8.
  • Sobel, (2016), Am. J. Obstet. Gynecol., 214, pp. 15, 10.1016/j.ajog.2015.06.067
  • Bradfield Strydom, M., Walpola, R.L., McMillan, S., Khan, S., Ware, R.S., and Tiralongo, E. (2022). Lived experience of medical management in recurrent vulvovaginal candidiasis: A qualitative study of an uncertain journey. BMC Womens Health, 22.
  • (2017), Rev. Med. Risaralda, 23, pp. 38
  • Cassone, (2015), BJOG Int. J. Obstet. Gynaecol., 122, pp. 785, 10.1111/1471-0528.12994
  • Sasani, (2021), Microb. Pathog., 154, pp. 104802, 10.1016/j.micpath.2021.104802
  • Terradez, (2009), Clin. Investig. Ginecol. Obstet., 36, pp. 194
  • Mtibaa, (2017), J. Mycol. Med., 27, pp. 153, 10.1016/j.mycmed.2017.01.003
  • Andrioli, (2009), Rev. Bras. Ginecol. Obs., 31, pp. 300, 10.1590/S0100-72032009000600006
  • (2012), Infect. Dis. Obstet. Gynecol., 2012, pp. 378640
  • (2013), Rev. Bras. Ginecol. Obs., 35, pp. 554, 10.1590/S0100-72032013001200005
  • (2007), Rev. Bras. Ginecol. Obs., 29, pp. 3
  • Marsh, (2014), Sex. Transm. Infect., 90, pp. 344, 10.1136/sextrans-2013-051381
  • Bradshaw, (2005), Obstet. Gynecol., 106, pp. 105, 10.1097/01.AOG.0000163247.78533.7b
  • Otero, (1998), Int. J. STD AIDS, 9, pp. 526, 10.1258/0956462981922764
  • Ginter, (2009), Mycoses, 35, pp. 177, 10.1111/j.1439-0507.1992.tb00841.x
  • Reed, (2003), J. Womens Health, 12, pp. 979, 10.1089/154099903322643901
  • Bardin, (2022), Rev. Bras. Ginecol. Obs. RBGO Gynecol. Obstet., 44, pp. 169, 10.1055/s-0041-1741536