Aislamiento y evaluación de compuestos bioactivos de origen vegetal.Contribución a la síntesis de derivados y análogos estructurales

  1. ORTEGA VIDAL, JUAN
Supervised by:
  1. Joaquin Altarejos Caballero Director
  2. Sofía Salido Co-director

Defence university: Universidad de Jaén

Fecha de defensa: 14 July 2021

Committee:
  1. Enrique Álvarez de Manzaneda Roldán Chair
  2. Justo Cobo Domingo Secretary
  3. Catalina Alarcón de la Lastra Romero Committee member
Department:
  1. QUÍMICA INORGÁNICA Y ORGÁNICA

Type: Thesis

Teseo: 680234 DIALNET

Abstract

The purpose of this Doctoral Thesis was to obtain both natural and synthetic bioactive organic compounds that could be of interest for the pharmaceutical and food industries. For this, some work has been done mainly on the recovery of phenolic compounds from agricultural wastes, such as the pruning woods of several fruit trees, isolating and characterizing around 40 natural products. A commercial extract of cranberry has also been chemically characterized, and some bioactive triterpenoids have been quantified in various organs of the olive tree. A method for isolating various bioactive phenols from olive oil has been described based on the use of the efficient countercurrent chromatography. An eco-sustainable synthesis of oleocanthal and oleacein, as well as their methylated derivatives, has been developed on a multigram scale. The synthesis of a simplified structural analogue of oleocanthal has been initiated with the aim of finding a "lead" to be developed in the future. Finally, the evaluation of some biological properties of the isolated and synthesized compounds has been developed in collaboration with other specialized research groups.