Cuando la pérdida duelebases biológicas de la frustración

  1. Torres Bares, Carmen
  2. Morillo-Rivero, Loida
  3. Papini, Mauricio
Revista interamericana de psicología = Interamerican journal of psychology

ISSN: 0034-9690

Year of publication: 2021

Volume: 55

Issue: 2

Type: Article

DOI: 10.30849/RIPIJP.V55I2.1443 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista interamericana de psicología = Interamerican journal of psychology


Frustration or psychological pain refers to a negative emotional experience derived from unexpected incentive loss. The scientific study of frustration with non-human animals is abundant and consistent, whereas human research on this topic seems to be more fragmentary because of the variety of conceptual, theoretical and experimental approaches. The main aim of this paper was to conduct a narrative review of the scientific literature about the psychological construct of frustration. With this goal in mind, we first described the consummatory successive negative contrast, a widely used animal model of psychological pain and frustration. We also conducted a systematic search of experimental studies aimed at inducing frustration in humans, reviewed studies focused on analyzing the relationship between physical and psychological pain, and selected experiments involving the manipulation (omission, devaluation) of social stimuli. A discussion of the implications of the results for basic and clinical research was finally included, with an especial emphasis in the current COVID-19 pandemic, a worldwide experience of incentive loss with relevant psychological consequences.

Bibliographic References

  • Abler, B., Walter, H. y Erk, S. (2005). Neural correlates of frustration. Neuroreport, 16, 669-672.
  • Amsel, A. (1992). Frustration theory: An analysis of dispositional learning and memory. Cambridge, UK: Cambridge University Press.
  • Balluerka, N., Gómez, J., Hidalgo, M.D., Gorostiaga, A., Espada, J.P. Padilla, J.L. y Santed, M.A. (2020). Las consecuencias Psicológicas de la COVID-19 y el confinamiento. Servicio de Publicaciones de la Universidad del País Vasco.
  • Berkowitz L (1989). Frustration-aggression hypothesis: Examination and reformulation. Psychological Bulletin, 106, 59-73.
  • Bernstein, M. J. y Claypool, H. M. (2012). Social exclusion and pain sensitivity: Why exclusion sometimes hurts and sometimes numbs. Personality and Social Psychology Bulletin, 38, 185-196.
  • Bolling, D. Z., Pitskel, N. B., Deen, B., Crowley, M. J., McPartland, J. C., Mayes, L. C. y Pelphrey, K. A. (2011). Dissociable brain mechanisms for processing social exclusion and rule violation. NeuroImage, 54, 2462-2471.
  • Borsook, T. K. y MacDonald, G. (2010). Mildly negative social encounters reduce physical pain sensitivity. Pain, 151, 372-377.
  • Bradley, M. M. y Lang, P. J. (1994). Measuring emotion: the self-assessment manikin and the semantic differential. Journal of Behavior Therapy and Experimental Psychiatry, 25(1), 49-59.
  • Brooks, S.K., Webster, R., Smith, L.E., Woodland, L., Wessely, S., Greenberg, N., Rubin, G.J. (2020). The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet, 395, 912-920.
  • Chen, Z., Reimer, C. y Verbruggen, F. (2020). Proximity and expectancy modulate response vigor after reward omission. PsyArXiv, en prensa.
  • Crespi, L. P. (1942). Quantitative variation of incentive and performance in the white rat. The American Journal of Psychology, 55, 467–517.
  • DeWall, C. N. y Baumeister, R. F. (2006). Alone but feeling no pain: Effects of social exclusion on physical pain tolerance and pain threshold, affective forecasting, and interpersonal empathy. Journal of Personality and Social Psychology, 91, 1-15.
  • DeWall, C. N., MacDonald, G., Webster, G. D., Masten, C. L., Baumeister, R. F., Powell, C. y Eisenberger, N. I. (2010). Acetaminophen reduces social pain: Behavioral and neural evidence. Psychological Science, 21, 931-937.
  • Dollard, J., Miller, N. E., Doob, L. W., Mowrer, O. H. y Sears, R. R. (1939). Frustration and aggression. Yale University Press.
  • Eisenberger, N. (2011). The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nature Reviews Neuroscience, 13, 421–434.
  • Eisenberger, N. I., Inagaki, T. K., Mashal, N. M. e Irwin, M. R. (2010). Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain, Behavior, and Immunity, 24, 558-563.
  • Eisenberger, N. I., Jarcho, J. M., Lieberman, M. D. y Naliboff, B. D. (2006). An experimental study of shared sensitivity to physical pain and social rejection. Pain, 126, 132-138.
  • Eisenberger, N. I., Lieberman, M. D. y Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302, 290-292.
  • Elliott, M. H. (1928). The effect of change of reward on the maze performance of rats. University of California Publications in Psychology, 4, 19-30.
  • Ellis, A. (2003). The relationship of rational emotive behavior therapy (REBT) to social psychology. Journal of Rational-Emotive and Cognitive-Behavior Therapy, 21(1), 5-20.
  • Festinger, L. (1961). The psychological effects of insufficient rewards. American Psychologist, 16(1), 1–11.
  • Flaherty, C. F. (1996). Incentive relativity. Cambridge, UK: Cambridge University Press.
  • Franchini, L., Ragone, N., Seghi, F., Barbini, B., y Colombo, C. (2020). Mental health services for mood disorder outpatients in Milan during COVID-19 outbreak: The experience of the health care providers at San Raffaele hospital. Psychiatry Research, 292, 113317.
  • Freud, S. (1958). "Types of Onset of Neurosis". En J. Strachey (Ed.), The Standard Edition of the Complete Psychological Works of Sigmund Freud (Vol. 12, pp. 227-230). London: Hogarth Press.
  • Genn, R. F., Tucci, S., Parikh, S. y File, S. E. (2004). Effects of nicotine and a cannabinoid receptor agonist on negative contrast: distinction between anxiety and disappointment? Psychopharmacology, 177, 93-99.
  • Glueck, A. C., Dennis, T. S., Perrotti, L. I., Torres, C., y Papini, M. R. (2015). Brain expression of pCREB in rats exposed to consummatory successive negative contrast. Neuroscience Letters, 587, 93-97.
  • Goldschmied, J. R., Cheng, P., Kemp, K., Caccamo, L., Roberts, J., y Deldin, P. J. (2015). Napping to modulate frustration and impulsivity: A pilot study. Personality and Individual Differences, 86, 164–167.
  • Gómez, M.J., Escarabajal, M.D., de la Torre, L., Tobeña, A., Fernández-Teruel, A. y Torres, C. (2009). Consummatory successive negative and anticipatory contrast effects in inbred Roman rats. Physiology & Behavior, 97, 374-380.
  • Gray, J. A. (1987). The psychology of fear and stress, 2nd ed. Cambridge, UK: Cambridge University Press.
  • Groschwitz, R. C., Plener, P. L. Groen, G., Bonenberger, M. y Abler, B. (2016). Differential neural processing of social exclusion in adolescents with non-suicidal self-injury: An fMRI study. Psychiatry Research: Neuroimaging, 255, 43-49.
  • Harrington N. (2006). Frustration intolerance beliefs: Their relationship with depression, anxiety, and anger, in a clinical population. Cognitive Therapy and Research, 30, 699-709.
  • Heeren, A., Dricot, L., Billieux, J. Philippot, P., Grynberg, D., de Timary, P. y Pierre Maurage, P. (2017). Correlates of social exclusion in social anxiety disorder: An fMRI study. Scientific Reports, 7, 260.
  • Jiménez-García, A. M., Ruíz-Leyva, L., Cendán, C. M., Torres C., Papini, M. R. y Morón, I. (2016). Hypoalgesia induced by reward devaluation in rats. PLoS One, 11, 1-15.
  • Jung, S.J., y Jung, J.Y. (2020). Mental health and psychological intervention amid COVID-19 outbreak: perspectives from South Korea. Yonsei Medical Journal, 61, 271-272.
  • Justel, N., Ruetti, E., y Mustaca, A. (2010). Aproximaciones teóricas al estudio del contraste sucesivo negativo consumatorio. Suma Psicológica, 17(2), 111-123. Disponible en:
  • Kawamoto, T., Onoda, K., Nakashima, K., Nittono, H., Yamaguchi, S. y Ura, M. (2012). Is dorsal anterior cingulate cortex activation in response to social exclusion due to expectancy violation? An fMRI study. Frontiers in Evolutionary Neuroscience, 4, 11.
  • Kramer, Y. y Rosenblum, L. A. (1970). Responses to “frustration” in one-year-old infants. Psychosomatic Medicine, 32, 243-258.
  • Krill, A. y Platek, S. M. (2009). In-group and out-group membership mediates anterior cingulate activation to social exclusion. Frontiers in Evolutionary Neuroscience, 1, 1.
  • Kross, E., Berman, M. G., Mischel, W., Smith, E. E. y Wager, T. D. (2011). Social rejection shares somatosensory representations with physical pain. Proceedings of the National Academy of Sciences USA, 108, 6270-6275.
  • Kumar, K.H. y Elavarasi, P. (2016). Definition of pain and classification of pain disorders. Journal of Advanced Clinical and Research Insights, 3, 87-90.
  • Lawson, R. (1965). Frustration. The Macmillan Company.
  • Lin, J. Y., Roman, C. y Reilly, S. (2009). Insular cortex and consummatory successive negative contrast in the rat. Behavioral Neuroscience, 123, 810-814.
  • Maier, N. R. F. y Ellen, P. (1959). The integrative value of concepts in frustration theory. Journal of Consulting Psychology, 23(3), 195–206.
  • Master, C. L., Eisenberger, N. I., Borofsky, L. A., Pfeifer, J. H., McNealy, K., Mazziotta, J. C. y Dapretto, M. (2009). Neural correlates of social exclusion during adolescence: Understanding the distress of peer rejection. Social Cognitive and Affective Neuroscience, 4, 143-157.
  • Master, S. L., Eisenberger, N. I., Taylor, S. E., Naliboff, B. D., Snirinyan, D. y Lieberman, M. D. (2009). A picture’s worth: Partner photographs reduce experimentally induced pain. Psychological Science, 20, 1316-1318.
  • Mediouni, M., Madiouni, R. y Kaczor-Urbanowicz, K.E. (2020). COVID-19: How the quarantine could lead to the depreobesity. Obesity Medicine, 19, 100255.
  • Miller, N. E. (1941). I. The frustration-aggression hypothesis. Psychological Review, 48(4), 337– 342.
  • Molden, D. C., Lucas, G. M., Gardner, W. L., Dean, K. y Knowles, M. L. (2009). Motivations for prevention or promotion following social exclusion: Being rejected versus being ignored. Journal of Personality and Social Psychology, 96, 415-431.
  • Moor, B. G., Güroglu, B., Op de Macks, Z. A., Rombouts, S. A. R. B., Van der Molen, M. W. y Crone, E. A. (2012). Social exclusion and punishment of excluders: Neural correlates and developmental trajectories. NeuroImage, 59, 708–717.
  • Morillo-Rivero, L.E., Ibáñez-Molina, A. J. y Torres, C. (2020). Successive negative contrast in humans: Dissociation between behavioral and affective measures of frustration. Learning and Motivation, 70, 1063.
  • Mustaca, A. E., y Papini, M. R. (2005). Consummatory successive negative contrast induces hypoalgesia. International Journal of Comparative Psychology, 18, 333-339.
  • Ortega, L. A., Daniel, A. M., Davis, J. B., Fuchs, P. N. y Papini, M. R. (2011). Peripheral pain enhances the effects of incentive downshifts. Learning and Motivation, 42, 203–209.
  • Ortega, L. A., Uhelski, M., Fuchs, P. N. y Papini, M. R. (2011). Impairment of recovery from incentive downshift after lesions of the anterior cingulate cortex: Emotional or cognitive deficits? Behavioral Neuroscience, 125, 988-995.
  • Ortega, L.A., Norris, J. N., Lopez-Seal, F., Ramos, T. y Papini, M. R. (2014). Correlates of recovery from incentive downshift: A preliminary selective breeding study. International Journal of Comparative Psychology, 27, 160-186.
  • Papini, M. R. (2003). Comparative psychology of surprising nonreward. Brain, Behavior and Evolution, 62, 83-95.
  • Papini, M. R. (2009). Role of opioid receptors in incentive contrast. International Journal of Comparative Psychology, 22, 170-187.
  • Papini, M. R. y Dudley, R. T. (1997). Consequences of surprising reward omissions. Review of General Psychology, 1(2), 175-197.
  • Papini, M. R. y Ortega, L. A. (2011). Endogenous opioids, opioid receptors, and incentive processes. En V. R. Preedy, R. R. Watson y C. R. Martin (Eds.), Handbook of behavior, food, and nutrition (pp. 1011-1019). New York: Springer.
  • Papini, M. R., Fuchs, P. N. y Torres, C. (2015). Behavioral neuroscience of psychological pain. Neuroscience and Biobehavioral Reviews, 48, 53-69.
  • Papini, M. R., Wood, M., Daniel, A. M. y Norris, J. N. (2006). Reward loss as psychological pain. International Journal of Psychology and Psychological Therapy, 6, 189-213.
  • Papini, S., Galatzer-Levy, I. R. y Papini, M. R. (2014). Identifying profiles of recovery from reward devaluation in rats. Behavioural Brain Research, 275, 212-218.
  • Pecoraro, N. y Dallman, M. F. (2005). c-Fos after incentive shifts: expectancy, incredulity, and recovery. Behavioral Neuroscience, 119, 366–387.
  • Pellegrini, S., Wood, M., Daniel, A. M. y Papini, M. R. (2005). Opioid receptors modulate recovery from consummatory successive negative contrast. Behavioural Brain Research, 164, 239-249.
  • Ramachandran, B.R.N., Romero, S.A., Born, J. Winkler, S. y Rama, R. R. (2017). Measuring Neural, Physiological and Behavioral Effects of Frustration. En J. Goh et al. (Eds.), The 17th International Conference on Biomedical Engineering IFMBE Proceedings, 61, 43-46.
  • Ramot, A. y Akirav, I. (2012). Cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala prevent the stress-induced enhancement of a negative learning experience. Neurobiology of Learning & Memory 97, 393-401.
  • Raven, J. C. (1975). Test de matrices progresivas. Escala general. Manual. Buenos Aires: Paidós.
  • Rich, B. A., Schmajuk, M., Perez-Edgar, K. E., Pine, D. S., Fox, N. A. y Leibenluft, E. (2005). The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. Biological Psychiatry, 58, 532-539.
  • Rodríguez-Rey, R., Garrido-Hernansaiz, H. y Collado, S. (2020). Psychological impact and associated factors during the initial stage of the coronavirus (COVID-19) pandemic among the general population in Spain. Frontiers in Psychology, 11, 1540. https://DOI.ORG/10.3389/fpsYG.2020.01540.
  • Rosenzweig, S. (1934). Types of reaction to frustration. The Journal of Abnormal and Social Psychology, 29(3), 298-300.
  • Rosenzweig, S. (1938). Frustration as an experimental problem. VI. General outline of frustration. Character & Personality; A Quarterly for Psychodiagnostic & Allied Studies, 7, 151-160.
  • Rosenzweig, S. (1945). The picture‐association method and its application in a study of reactions to frustration. Journal of Personality, 14, 3-23.
  • Rossi-Casé, L., Neer, R., Lopetegui, S., Doná, S. M., Biganzoli, B., y Garzaniti, R. (2016). Test de Raven: actualización de baremos en adolescentes argentinos y análisis del Efecto Flynn. Revista Iberoamericana de Diagnóstico y Evaluación-e Avaliação Psicológica, 42(2), 3-13.
  • Rowan, G. A. y Flaherty, C. F. (1987). The effect of morphine in the consummatory contrast paradigm. Psychopharmacology, 93, 51-58.
  • Sanz, J. (2001). An instrument to evaluate the efficacy of mood induction procedures: The Scale for Mood Assessment. Análisis y Modificación de Conducta, 27(111), 71–110. Recuperado de
  • Scheirer, J., Fernandez, R., Klein, J. y Picard, R. W. (2002). Frustrating the user on purpose: a step toward building an affective computer. Interacting with Computers, 14, 93-118.
  • Serafini, G., Parmigiani, B., Amerio, A., Agugla, A., Sher, L. y Amore, M. (2020). The psychological impact of COVID-19 on the mental health in the general population. QJM: An International Journal of Medicin, 13, 529–535.
  • Shigemura, J., Ursano, R. J., Morganstein, J. C., Kurosawa, M., y Benedek, D. M. (2020). Public responses to the novel 2019 coronavirus (2019‐nCoV) in Japan: Mental health consequences and target populations. Psychiatry and Clinical Neurosciences, 74(4), 281-282.
  • Siegrist, J., Menrath, I., Stöcker, T., Klein, M., Kellerman, T., Shah, N.J., Zilles, K., y Schneider, F. (2005). Differential brain activation according to social reward frustration. Neuroreport, 16, 1899-1903.
  • Song, M. (2020). Psychological stress responses to COVID-19 and adaptive strategies in China. World Development, 136, 105107.
  • Sugaya, N., Yamamoto, T., Suzuki, N., y Uchiumi, C. (2020). A real-time survey on the psychological impact of mild lockdown for COVID-19 in the Japanese population. Scientific Data, 7(1), 1-6.
  • Suso-Rivera, C. y Mártin-Brufau, R. (2020). How much support is there for the recommendations made to the general population during confinement? A study during the first three days of the COVID-19 quarantine in Spain. International Journal of Environmental Research and Public Health, 17, 4382.
  • Tchalova, K. y Eisenberger, N. I. (2015). How the brain feels the hurt of heartbreak: examining the neurobiological overlap between social and physical pain. Brain Mapping: An Encyclopedic Reference, 3, 15-20.
  • Thompson, J. B. (2019). Assessing the reward value of high concentrations of alcohol in rats. Doctoral Dissertation, Texas Christian University. .
  • Tinklepaugh, O. L. (1928). An experimental study of representative factors in monkeys. Journal of Comparative Psychology, 8(3), 197–236.
  • Tranel, D. T. (1983). The effects of monetary incentive and frustrative nonreward on heart rate and electrodermal activity. Psychophysiology, 20, 652-657.
  • Twenge, J. M., Baumeister, R. F., Tice, D. M. y Stucke, T. S. (2001). If you can’t join them, beat them: Effects of social exclusion on aggressive behaviour. Journal of Personality and Social Psychology, 85, 409-423.
  • Vadillo, S., Palomares, P. R., Pinto, M. E. y Almeida, E. (2015). Cannabinoides: utilidad en la práctica clínica. Acta Médica Grupo Ángeles, 13, 244-250.
  • Venkatesh, A. y Edirappu, S. (2020). Social distancing in covid-19: what are the mental health implications? The British Medical Journal, 369, m1379.
  • Vera-Villarroel, P. (2020). Psicología y COVID-19: un análisis desde los procesos psicológicos básicos. Cuadernos de Neuropsicología / Panamerican Journal of Neuropsychology, 14, 10-18.
  • Watson, D., Clark, L. A., y Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063–1070.
  • Weinstein, L. (1970). Magnitude of incentive contrast as a function of amount of verbal reward change. Psychonomic Science, 21, 65–66.
  • Weinstein, L. (1971). Effects of a reduction in reward magnitude on active avoidance behavior in humans. Psychonomic Science, 25, 205–206.
  • Weinstein, L. (1972). Negative contrast with humans as a function of emotionality. Journal of Psychology, 80, 161-165.
  • Weinstein, L. (1981). Incentive contrast effects in humans with monetary reinforcement and reaction time. Acta Psychologica, 47, 83-87.
  • Williams, K. D., Cheung, C. K. y Choi, W. (2000). Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology, 79, 748-762.
  • Wood, M. D., Norris, J. N., Daniel, A. M. y Papini, M. R. (2008). Trial-selective effects of U50, 488H, a κ-opioid receptor agonist, on consummatory successive negative contrast. Behavioural Brain Research, 193, 28-36.
  • Wood, M., Daniel, A. M. y Papini, M. R. (2005). Selective effects of the δ-opioid receptor agonist DPDPE on consummatory successive negative contrast. Behavioral Neuroscience, 119, 446-454.
  • Xiong, J., Lipsitz, O., Nasri, F., Lui, L. M., Gill, H., Phan, L., Chen-Li, D., Iacobucci, M., Ho, R., Majeed, A., y McIntyre, R. S. (2020). Impact of COVID-19 pandemic on mental health in the general population: A systematic review. Journal of Affective Disorders, 277(1), 55- 64.
  • Yu, R., Mobbs, D., Seymour, B., Rowe, J. B., y Calder, A. J. (2014). The neural signature of escalating frustration in humans. Cortex, 54, 165–178.
  • Yu, W., Guan, F., Fu, L., Long, C. y Yang, L. (2018). Disrupted physical pain sensation by social exclusion in women with dysmenorrhea. Journal of Pain Research, 11, 1469-1477.
  • Zhang, M., Zhang, P., Liu, Y., Wang, H., Hu, K., y Du, M. (2021). Influence of perceived stress and workload on work engagement in front‐line nurses during COVID‐19 pandemic. Journal of Clinical Nursing, 30(11-12), 1584-1595.