Nanopartículas Magnéticas en el Diagnóstico y Tratamiento del Cáncer
- Doello, Kevin 1
- Cabeza, Laura 1
- Ortiz, Raul 2
- Arias, Jose Luis 1
- Melguizo, Consolación 1
- Prados, Jose 1
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1
Universidad de Granada
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2
Universidad de Jaén
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ISSN: 0365-7965
Year of publication: 2015
Tome: 100
Issue: 796
Pages: 139-145
Type: Article
More publications in: Actualidad médica
Abstract
The advances in the field of nanotechnology include the development of new nanoparticles that are being used inside oncology, not only as new drugs transporters that are able to direct them to specific locations at the same time decreasing their systemic effects, furthermore, they generate localized heat (hyperthermia) as an antitumor therapy and for the localization and visualization of this type of pathology. In this context, nanoparticles with magnetic cores that have paramagnetic properties are gaining importance in the field of tumor diagnosis and also in the treatment, either only for applying hyperthermia phenomena or to combine them with targeting phenomenom of cytotoxic drugs by the addition of molecules onto the nanoparticle surface that recognize some kind of cancer biomarker (active targeting). The main objective of this review is to show the most relevant advances in the development of nanoplatforms that have magnetic cores and are a new strategy for the cancer treatment and/or diagnosis (theragnosis) by the mention of the main in vitro and in vivo assays, specially the clinical trials most important of this new therapeutic concept inside within the field of oncology.