Sensibilización central al dolor y anti-nocepción cardiovascular en fibromialgiaprotocolo de estimulación dolorosa lentamente repetida y su asociación con parámetros clínicos y cardiovasculares

Abstract

Fibromyalgia is a chronic pain syndrome characterized by generalized, diffuse and persistent pain whose etiology remains unknown. Its pathophysiology is related to central sensitization processes and dysfunction of pain inhibitory systems. However, no specific clinical markers have been found to facilitate its diagnosis. This doctoral thesis tests an evoked pain protocol based on slowly repeated painful stimulation. This protocol generated a pattern of progressive increase in the subjective intensity of pain in patients with fibromyalgia, which did not appear in healthy individuals or other chronic pain pathology (rheumatoid arthritis). In other way, the inverse association between blood pressure and experimental pain typically observed in healthy individuals was only found in fibromyalgia using this protocol and not when using static measures (threshold/tolerance). The slowly repeated evoked pain protocol is presented as a complementary diagnostic marker with potential clinical utility.