Una revisión de la literatura experimental sobre los efectos motivacionales del alcohol y su modulación por factores biológicos y ambientales

  1. Torre, María L. de la
  2. Escarabajal Arrieta, María Dolores
  3. Agüero, Angeles
Revista:
Anales de psicología

ISSN: 0212-9728 1695-2294

Año de publicación: 2013

Volumen: 29

Número: 3

Páginas: 934-943

Tipo: Artículo

DOI: 10.6018/ANALESPS.29.3.154561 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Anales de psicología

Resumen

El alcohol es posiblemente la droga psicoactiva más consumida en el mundo. La ingesta moderada es común, pero para algunos individuos el consumo de alcohol se convierte en un trastorno adictivo. La progresión desde un consumo moderado de alcohol hasta el abuso podría deberse a la existencia de una sensibilidad diferencial, genéticamente determinada, a los efectos reforzantes y aversivos del alcohol. Así mismo, se sugiere que factores ambientales, como el estrés, podrían intervenir en el inicio del alcoholismo, influyendo sobre dicha sensibilidad diferencial y, en última instancia, sobre el consumo de alcohol. En el presente trabajo se revisa la literatura experimental existente acerca de los elementos protagonistas en la relación entre estrés y etanol. Por una parte se revisan los principales mode-los de estrés existentes y, por otra, se aborda el estudio de las propiedades reforzantes y aversivas de esta droga, incluyendo datos sobre la influencia de variables como la edad, el sexo, y la experiencia previa con la droga. Fi-nalmente, se expone un resumen de los datos existentes sobre la investiga-ción con animales sobre la influencia del estrés en la percepción de las pro-piedades motivacionales opuestas del etanol. Nuestro objetivo es contribuir a clarificar el conocimiento existente acerca de las relaciones entre determinados factores biológicos (como el sexo o la edad) y ambientales (experiencia previa y estrés), y la conducta de ingesta de alcohol, poniendo de manifiesto la importancia de algunos factores de riesgo para el desarrollo del alcoholismo

Referencias bibliográficas

  • Adinoff, B., Iranmanesh, A., Veldhius, J., y Fisher, L. (1998). Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence. Alcohol Health Research, 22, 67-72.
  • Alonso, J., y Navarro, E. (1993). El estrés. Medicina clínica, 100, 26-28.
  • Anderson, R. I., Varinskaya, E. I. y Spear, L. P. (2010). Ethanol-induced conditioned taste aversion in male sprague-dawley rats: impact of age and stress. Alcohol: Clinical and Experimental Research, 34(12), 2106-2115. doi: 10.1111/j.1530-0277.2010.01307.x.
  • Aragón, C., Sternklar, G., y Amit, Z. (1985). A correlation between voluntary ethanol consumption and brain catalase activity in the rat. Alcohol, 2, 353-356. doi: 10.1016/0741-8329(85)90074-6.
  • Blanchard, B. A. y Glick, S. D. (1995). Sex differences in mesolímbico dopamine responses to ethanol and relationship to ethanol intake in rats. Recent Developments in Alcoholism, 12, 231-241.
  • Blanchard, B. A., Steindorf, S., Wang, S. y Glick, S. D. (1993). Sex differences in ethanol-induced dopamine release in nucleus accumbens and in ethanol consumption in rats. Alcoholism: Clinical and Experimental Research, 17, 968-973. doi: 10.1111/j.1530-0277.1993.tb05650.x.
  • Boyle, A. E., Smith, B. R., Spivak, K. y Amit, Z. (1994). Voluntary ethanol consumption in rats: the importance of the exposure paradigm in determining the final intake outcome. Behavioral Pharmacology, 5, 502-512. doi: 10.1097/00008877-199408000-00011.
  • Briand, L. y Blendy, J. A. (2010). Molecular and genetic substrates linking stress and addiction. Brain Research, 1314, 219-234. doi:10.1016/j.brainres.2009.11.002.
  • Broadbent, J., Muccino, K. J., y Cunningham, C. L. (2002). Ethanol-induced conditioned taste aversion in 15 inbred mouse strain. Behavioral Neuroscience, 116, 138-148. doi: 10.1037//0735-7044.116.1.138.
  • Busse, G. D., Lawrence, E. T. y Riley, A. L. (2005). The effects of alcohol preexposure on cocaine, alcohol and cocaine/alcohol place conditioning. Pharmacology, Biochemistry & Behavior, 81, 459-465. doi: 10.1016/j.pbb.2005.04.003.
  • Caihol, S. y Mormede, P. (2001). Sex and strain differences in ethanol drinking: effects of gonadectomy. Alcohol: Clinical and Experimental Research, 25, 594-599. doi: 10.1111/j.1530-0277.2001.tb02255.x.
  • Camarini, R., Pautassi, R., Méndez, M., Quadros, I. M., Souza-Formigoni, M. L. y Boerngen-Lacerda R. (2010). Behavioral and neurochemical studies in distinct animal models of ethanol's motivational effects. Current Drug Abuse Reviews, 3(4), 1-17. doi:10.2174/1874473711003040205.
  • Chester, J. A., de Paula Barrenha, G., y DeMaria, A. (2006). Different effects of stress on alcohol drinking behavior in male and female mice selectively bred for high alcohol preference. Alcohol & Alcoholism, 41, 44-53. doi: 10.1093/alcalc/agh242.
  • Cunningham, C. L., Clemans, J., y Fidler, T. (2002). Injection timing determines wthether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacology, Biochemestry & Behavior,72(3), 659-68. doi: 10.1016/S0091-3057(02)00734-7.
  • Cunningham, C. L., Fidler, T. y Hill, K. G. (2000). Animal models of alcohol's motivational effects. Alcohol Research & Health, 24(2), 85-92.
  • Cunningham, C. L. y Gremel, C. M. (2006). Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. Pharmacology, Biochemistry & Behavior, 85, 612-619. doi: 10.1016/j.pbb.2006.10.016.
  • Cunningham, C. L. y Ignatoff, D. L. (2000). Genetic differences in ethanol-induced conditioned place aversion. Alcoholism, Clinical and Experimental Research, 24: 57A.
  • Cunningham, C. L., Tull, L. E., Rindal, K. E., y Meyer, P. J. (2002). Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect. Psychopharmacology, 160, 414-424. doi: 10.1007/s00213-001-0990-1.
  • Doremus, T. L., Brunell, S. C., Rajendran, P. y Spear, L. P. (2005). Factors influencing elevated ethanol consumption in adolescent relative to adult rats. Alcohol: Clinical and Experimental Research, 29, 1796-808. doi: 10.1097/01.alc.0000183007.65998.aa
  • Duranceaux, N., Schuckit, M. A., Eng, M. Y., Robinson, S. K., Carr, L. G. y Wall, T. L. (2006). Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians. Alcoholism, Clinical and Experimental Research, 30, 1470-1478. doi: 10.1111/j.1530-0277.2006.00178.x.
  • Ericson, M., Molander, A., Lof, E., Engel, J. y Soderpaim, B. (2003). Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. European Journal of Pharmachology, 467, 85-93. doi: 10.1016/S0014-2999(03)01564-4.
  • Escarabajal, M. D. (2003). Alteraciones genéticas relacionadas con el alcoholismo. Revista de Neurología, 37 (5), 471-480.
  • Escarabajal, M. D., De Witte, P. y Quertemont, E. (2003). Role of acetaldehyde in ethanol-induced conditioned taste aversión in rats. Psychopharmacology, 167, 130-136. doi: 10.1007/s00213-003-1427-9.
  • Fernández-Teruel, A., Driscoll, P., Gil, L., Aguilar, R., Tobeña, A. y Escorihuela, R. (2002). Enduring effects of environmental enrichment on novelty seeking,saccharin and ethanol intake in two rat lines (RHA/Verh and RLA/Verh) differing in incentive-seeking behavior. Pharmacology, Biochemistry and Behavior, 73, 225-231. doi: 10.1016/S0091-3057(02)00784-0.
  • Fidler, T. L., Bakner, L. y Cunningham, C. L. (2004). Conditioned place aversion induced by intragastric administration of ethanol in rats. Pharmacology, Biochemistry & Behavior, 77, 731-743. doi:10.1016/j.pbb.2004.01.010.
  • Fuchs, E. y Flügge, G. (2003). Chronic social stress: effects on limbic brain structures. Physiology & Behavior, 79, 417-427. doi: 10.1016/S0031-9384(03)00161-6.
  • Funk, D., Hurding, S., Juzytsch, W. y Le, A. D. (2005). Effects of unconditioned and conditioned social defeat on alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology, 183, 341-349. doi: 10.1007/s00213-005-0194-1.
  • Funk, D., Vohra, S., y Le, A. (2004). Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning. Psychopharmacology, 176, 82-87. doi: 10.1007/s00213-004-1859-x.
  • Gambrana, C. (2007). Experimental protocols for the study of stress in animals and humans. En S. Yehuda, y D. I. Mostofsky (Eds.), Nutrient, Stress and Medical Disorders (pp. 21-35). New Jersey: Humana Press Inc.
  • García-Burgos, D., González, F., Manrique, T. y Gallo, M. (2009). Patterns of Ethanol Intake in Preadolescent, Adolescent, and Adult Wistar Rats Under Acquisition, Maintenance, and Relapse-Like Conditions. Alcoholism: Clinical and Experimental Research, 33(4), 722-728. doi: 10.1111/j.1530-0277.2008.00889.x.
  • Green, A. S. y Grahame, N. J. (2008). Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?. Alcohol, 42(1), 1-11. doi: 10.1016/j.alcohol.2007.10.005.
  • Grigson, P. (1997). Conditioned taste aversions and drugs of abuse: a reinterpretation. Behavioral Neuroscience, 111(1), 129-136.
  • Guerri, C. y Pascual, M. (2010). Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. Alcohol, 44, 15-26. doi: 10.1016/j.alcohol.2009.10.003.
  • Guitart-Masip, M., Gimenez-Llort, L., Fernández-Teruel, A., Cañete, T., Tobeña, A., Ove Ögren, S. O., Terenius, L. y Johansson, B. (2006). Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures. European Journal of Neuroscience, 23, 531-540. doi: 10.1111/j.1460-9568.2005.04556.x.
  • Hegarty, A. A. y Vogel, W. H. (1993). Modulation of the stress response by ethanol in the rat frontal cortex. Pharmacology, Biochemistry and Behavior, 45, 297-299. doi: 10.1016/0091-3057(93)90247-Q.
  • Herman, J. P. y Cullinan, W. E. (1997). Neurocircuitry of stress: central control of the hypothalamo-pituitary-adreno-cortical axis. Trends in Neuroscience, 20, 78-84. doi: 10.1016/S0166-2236(96)10069-2.
  • Kamenetzky, G. V., Cuenya, L., Pedrón, V. y Mustaca, A. E. (2007). Condicionamiento de lugar en ratas y etanol. International Journal of Psychology and Psychological therapy, 7 (3), 321-333.
  • Koob, G. (2006). The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction, 101, 23-30. doi: 10.1111/j.1360-0443.2006.01586.x.
  • Koob, G. y LeMoal, M. (2008). Addiction and the brain antireward system. Annual Reviews of Psychology, 59, 29-53. doi:10.1146/annurev.psych.59.103006.093548.
  • Kreek, M. J. y Koob G. F. (1998). Drug dependence: stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence, 51, 23-47. doi: 10.1176/appi.ajp.2007.05030503.
  • Lancaster, F. E., Brown, T. D., Coker, K. L., Elliott, J. A. y Wren, S. B. (1996). Sex differences in alcohol preference and drinking patterns emerge during the early postpubertal period. Alcoholism: Clinical and Experimental Research, 20, 1043-1049. doi: 10.1111/j.1530-0277.1996.tb01945.x.
  • Le, A. D., Israel, Y., Juzytsch, W., Quan B y Harding S. (2001). Genetic selection for high and low alcohol consumption in a limited-acces paradigm. Alcoholism: Clinical and Experimental Research, 25, 1613-620. doi: 10.1111/j.1530-0277.2001.tb02168.x.
  • Liu, C., Showalter, J. y Grigson, P. (2009). Ethanol-induced conditioned taste avoidance: reward or aversion?. Alcoholism: Clinical and Experimental Research, 33 (3), 522-530. doi: 10.1111/j.1530-0277.2008.00865.x.
  • Lu, L., Shepard, J. D., Hall, F. S. y Shaham Y. (2003). Effect of environmental stressors on opiate and psychoestimulant reinforcement, reinstatement and discrimination en rats: a review. Neuroscience & Biobehavioural Reviews, 27, 457-491. doi: 10.1016/S0149-7634(03)00073-3.
  • McDevitt-Murphy, M. E., Williams, J. L., Bracken, K. L., Fields, J.A., Monahan, C. J. y Murphy, J. G. (2010). PTSD symptoms, hazardous drinking, and health functioning among U.S. OEF and OIF veterans presenting to primary care. Journal of Traumatic Stress, 23(1), 108-111. doi: 10.1002/jts.20482.
  • Melis, M., Diana, M., Enrico, P., Marinelli, M. y Brodie, M. (2009). Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress. Alcohol, 43, 531-539. doi: 10.1016/j.alcohol.2009.05.004.
  • Miczek, K., Yap, J., y Covington, H. (2008). Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake. Pharmacology & Therapeutics, 120, 102-128. doi:10.1016/j.pharmthera.2008.07.006.
  • Pani, L., Pordella, A. y Gessa, G. L. (2000). The role of stress in the pathophysiology of the dopaminergic system. Molecular Psychiatry, 5, 14-21.
  • Pautassi, R. M., Camarini, R., Quadros, I. M., Miczek, K. A. e Israel Y. (2010). Genetic and Environmental Influences on Ethanol Consumption: Perspectives From Preclinical Research. Alcoholism: Clinical and Experimental Research, 34(6), 976-987. doi: 10.1111/j.1530-0277.2010.01172.x.
  • Pautassi, R. M., Nizhnikov, M. E. y Spear, N. E. (2009). Assessing appetitive, aversive, and negative ethanol-mediated reinforcement. Neurocience and Biobehavioral Reviews, 33, 953-974. doi:10.1016/j.neubiorev.2009.03.008.
  • Philpot, R. M., Badanich, K. A. y Kirstein, C. L. (2003). Place conditioning: Age-related changes in the rewarding and aversive effects of alcohol.Alcoholism clinical and experimental research, 27, 593-599. doi: 10.1111/j.1530-0277.2003.tb04395.x.
  • Quertemont, E., Escarabajal, M. D. y De Witte, P. (2003). Role of catalse in ethanol-induced conditioned taste aversion: a study with 3-amino-1,2,4-triazole. Drug and Alcohol Dependence, 70, 77-83. doi: 10.1016/S0376-8716(02)00341-1.
  • Roma, P., Davis, C. M., Kohut, S. J., Huntsberry, M. E. y Riley, A. L. (2008). Early maternal separation and sex differences in the aversive effects of amphetamine in adults rats. Physiology & Behavior, 93, 897-904. doi: 10.1016/j.physbeh.2007.12.007.
  • Roma, P., Rinker, J., Serafine, K., Chen, S., Barr, C., Cheng, K., Rice, K. C. y Riley, A. L. (2008). Genetic and early environmental contributions to alcohol's aversive and physiological effects. Pharmacology, Biochemistry & Behavior, 91, 134-139. doi: 10.1016/j.pbb.2008.06.022.
  • Sakusic, A., Avdibegovic, E., Zoricic, Z., Pavlovic, S., Gaspar, V. y Delic, A. (2010). Relationship between anger, alcoholism and symptoms of posttraumatic stress disorders in war veterans. Medical Archives, 64(6), 354-358.
  • Samson, H. (1986). Initiation of ethanol reinforcement using a sucrose-sustitution procedure in food-and water-stated rats. Alcoholism: Clinical and Experimental Research, 10, 436-442.
  • Sanchis-Segura, C. y Spanagel, R. (2006). Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addiction Biology, 11, 2-38. doi: 10.1111/j.1369-1600.2006.00012.x.
  • See, R. E. y Waters, R. P. (2011). Pharmacologically-induced stress: a cross-species probe for translational research in drug addiction and relapse. American Journal of Traslational Research, 3(1), 81-89.
  • Shina, R. (2005). Stress and drug abuse. En T. Steckler, N. Kalin y J. Reul (Eds.), Handbook of stress and the brain (pp. 333-356). Amsterdam: Elsevier.
  • Shoaib, M., y Almeida, O. (1996). Absence of tolerance to the aversive stimulus properties of ethanol following oral ethanol self-administration. Alcohol, 13(2), 175-180. doi: 10.1016/0741-8329(95)02039-X.
  • Song, M., Wang, X. Y., Zhao, M., Wang, X.-Y., Zhai, H. F., y Lu, L. (2007). Role of stress in acquisition of alcohol-conditioned place preference in adolescent and adult mice. Alcoholism: clinical and experimental research, 31(12), 2001-2005. doi: 10.1111/j.1530-0277.2007.00522.x.
  • Sorge, R. E., Fudge, M. A. y Parker, L. A. (2002). Effect of sodium deprivation on morphine-and lithium-induced conditioned salt-avoidance and taste reactivity. Psychopharmacology, 160, 84-91. doi: 10.1007/s00213-001-0956-3.
  • Spear, L. P. y Varlinskaya, E. I. (2010). Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science?. Developmental Psychobiology, 52, 236-43. doi: 10.1002/dev.20457.
  • Sperling, R. E., Gomes, S. M., Sypek, E. I., Carey, A. N. y McLaughlin, J. P. (2010). Endongenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration. Psychopharmacology, 210, 199-209. doi: 10.1007/s00213-010-1844-5.
  • Steckler, T. (2005). The neuropsychology of stress. En T. Steckler, N. H. Kalin, y J. M. Reul (Eds.), Handbook os stress and the Brain (pp. 25-42). Amsterdam: Elsevier.
  • Tzschentke, T. (1998). Measuring the reward with the conditioned place preference paradigm: a comprehensive review of drigs effects, recent progress and new issues. Progress in Neurobiology, 56, 613-672. doi: 10.1016/S0301-0082(98)00060-4.
  • Vengeliene, V., Siegmund, S., Singer, M., Sinclair, J., Li, T. y Spanagel, R. (2003). A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcoholism: Clinical and Experimental Research, 27, 1048-1054. doi:10.1097/01.ALC.0000075829.81211.0C.
  • Vetter-O'Hagen, C., Varlinskaya, E. y Spear, L. (2009). Sex differences in ethanol intake and sensitivity to aversive effects during adolescence and adulhood. Alcohol & Alcoholism, 44(6), 547-554. doi:10.1093/alcalc/agp048.
  • Wilson, M., Burghardt, P., Wilkinson, M. y Primeaux, S. (2004). Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females. Pharmacology, Biochemistry & Behavior, 78, 445-448. doi: 10.1016/j.pbb.2004.04.017.
  • Yap, J. J. y Miczek, K. A. (2008). Stress and rodent models of VTA-accumbens-PFC-amygdala circuit. Drug Discovery Today: Disease Models, 5(4), 259-270. doi: 10.1016/j.ddmod.2009.03.010.
  • Zimmermann, U. S., Blomeyer, D., Laucht, M. y Mann, K. F. (2007). How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. Pharmacology, Biochemistry & Behavior, 86, 246-262. doi: 10.1016/j.pbb.2006.09.024.