Inmunomodulación ejercida por los ácidos grasos de la dieta en animales de experimentación y humanos
- Pablo Martínez, Manuel Antonio de
- Ortega Morente, Elena
- Gallego Cabrera, A. María
- Álvarez Nieto, Carmen
- Álvarez de Cienfuegos López, Gerardo
ISSN: 0017-3495, 1988-4214
Argitalpen urtea: 2000
Alea: 51
Zenbakia: 3
Orrialdeak: 190-195
Mota: Artikulua
Beste argitalpen batzuk: Grasas y aceites
Laburpena
Several studies have reported that fatty acids act as modulatory agents of immune response of experimental animals and humans. In this paper, we do and overview of the performed studies by using of unsaturated fatty acids and their influence on several immunitary parameters in studies carried out <i>in vitro</i> as well as <i>ex vivo</i>. It has been shown that unsaturated fatty acids are involved in the reduction of lymphocyte proliferation, cytokine production and natural killer cell activity. On the other hand, in this article we have reviewed the mechanisms by which fatty acids modulate the immune response: I) membrane fluidity alteration; II) production of lipid peroxides; III) eicosanoid production; IV) gene expression modulation.