Efecto de fenoles del olivo en procesos de hipoxia y neurodegeneración

Résumé

In this doctoral thesis we have evaluated the effect of HT and TYR in cancer and stroke, two hypoxia-related diseases, and in one of the most frequent amyloid diseases, Parkinson´s Disease (PD). In the studies performed with MCF-7 breast cancer cells under hypoxic conditions, we described that HT reduced the level of oxidative stress and the accumulation of HIF-1α, amarker of poor prognosis. By using a model of tMCAO in mice, we have shown that the therapeutic use of a HT-enriched diet improves the physical and cognitive status and positively affects key parameters for ischemic stroke recovery. Finally, the analysis of the effect of TYR in C. elegans models of PD demonstrated the neuroprotective potential of this compound against dopaminergic degeneration and toxicity induced by the aggregation of α-synuclein. In conclusion, the results obtained in this doctoral thesis point to HT and TYR as promising bioactive compounds with beneficial effects in these pathologies.