Análisis de la expresión y de la modulación de lncRNAs en el desarrollo cardiaco

Résumé

The development of the heart is a complex process that is regulated space-temporarily both transcriptionally and post-transcriptionally. In this context we have studied the role during the embryonic development and in the adult stage of lncRNAs previously described in the literature showing that these have defined expression profiles and differential expressions in the different cardiac chambers. In the same way, we have identified new lncRNAs whose expression during cardiac development suggests an important role in the maturation of atrial chambers. We have also studied the possible modulation of these by different cardiac transcription factors, by the signaling pathway Pitx2> Wnt> microRNAs and by pro-hypertrophic and pro-arrhythmogenic factors. These tests have demonstrated a differential modulation of the different lncRNAs by these mediators, which suggests their role in different pathologies. Together these data indicate the importance of this class of RNA in both development and cardiac pathologies