Genes de la inmunidad innata y resistencia a la infección por VIH-1 en usuarios de drogas por vía parenteral

  1. María del Rocío Herrero del Río
Supervised by:
  1. Antonio Jose Caruz Arcos Director
  2. Luis M. Real Director

Defence university: Universidad de Jaén

Year of defence: 2016

Committee:
  1. María Teresa Rugeles López Chair
  2. Alejandro Vallejo Tiller Secretary
  3. Ezequiel Ruiz-Mateos Carmona Committee member
Department:
  1. BIOLOGÍA EXPERIMENTAL

Type: Thesis

Teseo: 443135 DIALNET

Abstract

The main objective of this work was to analyse 21 innate immunity genes and its association with HIV-1 infection. We have identified an association between lower HIV-1 infection risk by parenteral route and rs2842704 (C4BPA), rs1567190 (CR2) and a haplotype within the CD209 promoter (rs4804803, rs735239 and rs735240). The phenotypic characterization of these associations revealed that in both cases the protective genotypes were correlated with either a lower mRNA expression levels or a lower promoter activity. The rs368234815 polymorphism located in IFNL4, also confers protection to HIV-1 infection by parenteral route. These variations could be used for evaluating the individual HIV-infection risk and could have a value as new pharmacogenetics markers in the next generation HIV-1 vaccine programs.