Una tarea de generación aleatoria con mínimas demandas de memoria para la enfermedad de alzheimer leve

  1. María Rosario García Viedma 1
  2. Sara Fernández Guinea 2
  3. Rafael Martos 1
  4. Ana Raquel Ortega Martínez 1
  1. 1 Universidad de Jaén
    info

    Universidad de Jaén

    Jaén, España

    ROR https://ror.org/0122p5f64

  2. 2 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Revista:
Acción psicológica

ISSN: 1578-908X

Año de publicación: 2015

Volumen: 12

Número: 1

Páginas: 47-56

Tipo: Artículo

DOI: 10.5944/AP.12.1.15317 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Acción psicológica

Objetivos de desarrollo sostenible

Resumen

Mild Alzheimer’s disease patients show difficulties in everyday activities caused by attentional control involvement. They reveal qualitative differences between normal and pathological aging. Random generation tasks have been proposed as sensitive test to assess this attentional ability; however, their application to elderly people and AD patients could be biased by memory demands. In order to specifically evaluate attentional control in these subjects, we design a manual random generation task, with minimum memory requirements. It was applied to both healthy elderly people and patients with mild AD. The achieved results revealed significant differences between both groups on the diverse random indexes, showing AD patients more difficulties when interruption or avoiding answering patterns or stereotyped sequences is required, and also in switching strategies. These findings confirm that this manual random generation task allow to evaluate attentional control in a delimited way in elderly people. Besides, it is sensitive in normal aging and neurodegenerative process discrimination. Then, manual random generation tasks could be proposed in early diagnosis of Alzheimer’s disease.

Referencias bibliográficas

  • Alberoni, M., Baddeley, AD., Della Sala, S., Logie, R H. y Spinnler H. (1992). Keeping track of a conversation: impairments in Alzheimer’s disease. International Journal of Geriatric Psychiatry, 7, 639–646.
  • American Psychiatric Association (2002). Diagnostic and Statistical Manual of Mental Disorders DSM-IV-R. Washington: Autor.
  • Amieva, H., Phillips, K H., Della Sala, S. y Henry, J. D. (2004). Inhibitory functioning in Alzheimer`s disease. Brain, 127, 949-964.
  • Azouvi, P., Jokic, C., Van der Linden, M., Marlier, N. y Bussel, B. (1996). Working memory and supervisory control after severe closed-head injury. A study of dual task performance and random generation. Journal of Clinical and Experimental Neuropsychology, 18(3), 317-337.
  • Baddeley, A D. (1986). Working memory. Oxford: Clarendon Press.
  • Baddeley, A. (1998).Working memory. Life Sciences, 321, 167-173.
  • Baddeley, A D. (1996). Exploring the Central Executive. The Quarterly Journal of Experimental Psychology, 49A(1), 5-28.
  • Baddeley, A D., Baddeley, H., Bucks, R S. y Wilcox, G K. (2001). Attentional control in Alzheimer`s disease. Brain, 124, 1492-1508.
  • Baddeley, A D., Emslie, H., Kolodny, J. y Duncan, J. (1998). Random generation and the executive control of working memory. Quarterly Journal of Experimental Psychology, 51A, 819-852.
  • Balota, D. A. y Faust, M. E. (2001). Attention in dementia of the Alzheimer`s type. En F. Boller y S F. Cappa (Eds.), Handbook of Neuropsychology (2ª Ed., pp. 51- 80). New York: Elsevier Science.
  • Belleville, S., Chertkow, H. y Gauthier, S. (2007). Working memory and control of attention in persons with Alzheimer’s disease and mild cognitive impairment. Neuropsychology, 21, 458–459.
  • Blessed, G., Tomlison, B. E. y Roth, M. (1968). The association between quantitative measures of dementia and senile change in the cerebral grey matter of elderly subjects. British. Journal of Psychiatry, 114, 797-811.
  • Brugger, P., Monsch, A. U., Salmon, D. P. y Butters, N. (1996). Random number generation in dementia of the Alzheimer type: A test of frontal executive functions. Neuropsychologia, 34(2), 97-103.
  • Daniels, C., Witt, K., Wolff, S., Jansen, O. y Deuschl, G. (2003). Rate dependency of the human cortical network subserving executive functions during gen- eration of random number series—a functional magnetic resonance imaging study. Neuroscience Letters, 345(1), 25-28.
  • Della Sala, S. y Logie, R. H. (2001). Theoretical and practical implications of dual-task performance in Alzheimer’s disease. Brain, 124, 1479-1481.
  • Duchek, J. M., Hunt, L. A., Ball, K., Buckles, V. y Morris, J. C. (1998). Attention and driving performance in Alzheimer’s disease. Journal of Gerontology: Psychological Science, 53B(2), 130-141.
  • Evans F. J. (1978). Monitoring attention development by random number generation: An index by measure subjective randomness. Bulletin of Psychonomic Society, 12, 35-38.
  • Friedman, N. P. y Miyake, A. (2004). The relations among inhibition and interference control functions: a latent-variable analysis. Journal of Experimental Psychology: General, 133, 101-135.
  • Ginsburg, N. y Karpiuk, P (1994). Random generation: Analysis of the responses. Perceptual and Motors Skill, 79, 1059-1067.
  • Grady, C. L., Haxby, J. V., Horwitz, B., Sundaram, M., Berg, G., Schapiro, M B., Friedland, R P. y Rapoport, S. I. (1988). Longitudinal study of the ear- ly neuropsychological and cerebral metabolic changes in dementia of Alzheimer type. Journal of Clinical and Experimental Neuropsychology, 10, 576- 596.
  • Jacobs, D. M., Gurvit, H., Dooneief, G., Marder, K., Bell, K. L. y Sterm, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer’s disease. Neurology, 45, 957-962.
  • Joppich, G., Däuper, J., Dengler, R., Johannes, S., Rodriguez-Fornells, A. y Münte, T. F. (2004). Brain potentials index executive functions during random number generation. Neuroscience Research, 49, 157- 164.
  • Lemaire, P., Abdi, H. y Fayol, M. (1996). The role of working memory resources in simple cognitive arithmetic. European Journal of Cognitive Psychology, 8, 73-103.
  • Lobo, A., Esquerra, A., Burgada, F. G., Sala, M. y Sevá, A. (1979). Mini-Examen Cognoscitivo (un test sencillo, práctico, para detectar alteraciones intelectuales en pacientes médicos). Actas Luso Españolas de. Neurología y Psiquiatría, 7, 189-202.
  • Logie, R. H., Gilhooly, K. J., y Wynn, V. (1994). Counting on working memory in arithmetic problem solving. Memory and Cognition, 22, 395-410.
  • Martini, L., Domahs, F., Benke, T. y Delazer, M. (2003). Everyday numerical abilities in Alzheimer’s disease. Journal of International Neuropsychological Society, 9, 871-878.
  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. y Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDSADRDA work group under the auspices of Department of Health and Human Services Task Forces on Alzheimer’s disease. Neurology, 34, 939-944.
  • Miyake, A., Friedman, N. P., Emerson, M. I., Witzki, A. H., Howerter, A. y Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex “Frontal Lobe” task: A latent variable analysis. Cognitive Psychology, 41, 49-100.
  • Morris, R. G. (1994). Working Memory in AlzheimerType Dementia. Neuropsychology, 8(4), 544-554.
  • Norman, D. A. y Shallice, T. (1986). Attention to action: Willed and automatic control of behavior. En R J. Davison, G E. Schwartz y D. Shapiro (Eds.), Consciousness and self-regulation: Advances in research and theory (Vol. 4, pp. 1-18). New York: Plenum Press.
  • Perry, R. J. y Hodges, J. R. (1999). Attention and executive deficits in Alzheimer’s disease. Brain, 12, 383- 404.
  • Perry, R. J., Watson, P. y Hodges J. R. (2000). The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer’s disease: relationship to episodic and semantic memory impairment». Neuropsychologia, 38, 252-271.
  • Peters, M., Giesbrecht, T., Jelicic, M. y Merckelbach, H. (2007). The Random Number Generation task: Psychometric properties and normative data of an executive function task in a mixed sample. Journal of the International Neuropsychological Society, 13, 626- 634.
  • Pollux, P. M., Wester, A. y De Haan, E. H. (1995). Random generation deficit in alcoholic Korsakoff patients. Neuropsychologia, 33, 125-129.
  • Price, B. H., Gurvit, H., Weintraub, S., Geula, C., Leimkhuler, E. y Mesulam, M. (1993). Neuropsychological patterns and language deficits in 20 consecutive cases of autopsy-confirmed Alzheimer. Archives of Neurology, 50, 931-937.
  • Rabinowitz, F. M., Dunlap, W. P., Grant, M. J. y Campione, J. C. (1989). The rules used by children and adults in attempting to generate random numbers. Journal of Mathematical Psychology, 33, 227-287.
  • Robertson, C., Hazlewood, R. y Rawson, M. D. (1996). The effects of Parkinson's disease on the capacity to generate information randomly. Neuropsychologia, 34(11), 1069-1078.
  • Salamé, P. y Danion, J M. (2007). Inhibition of inappropiate responses is preserved in the think-no-think and impaired in the random number generation tasks in schizophrenia. Journal of the International Neurospychological Society, 13, 277-287.
  • Schneider, W., Eschman, A. y Zuccolotto, A. (2002). Eprime User’s Guide. Psychology Software Tools Inc., Pittsburgh.
  • Shallice, T. y Burgess, P. W. (1991). Deficits in strategy application following frontal lobe damage in man. Brain, 114, 727-741.
  • Splieler, D. H., Balota, D. A. y Faust, M. E. (1996). Stroop performance in younger adults, healthy adults, and individuals with senile dementia of the Alzheimer`s type. Journal of Experimental Psychology: Human Perception and Performance, 22, 461- 479.
  • Towse, J. N. (1998). On random generation and the central executive of working memory. British Journal of Psychology, 89(1), 77-101.
  • Towse, J. N. y Neil, D. (1998). Analyzing human random generation behaviour: A review of methods used and a computer program for describing performance. Behaviour Research Methods, Instruments, y Computers, 30(4), 583-591.
  • Towse, J. N. y Valentine, J. D. (1997). Random generation of numbers: A search for underlying processes. European Journal of Cognitive Psychology, 9(4), 381- 400.
  • Wechsler, D. (2004). Escala de memoria de Wechsler (III) [Wechsler Memory Scale]. Madrid, España: TEA.
  • Wechsler, D. y Kaufman, A. (2001). Escala de inteligencia de Wechsler para adultos (IV)[Wechsler Adult Intelligence Scale (IV)]. Madrid, España: TEA.
  • Williams, M. A, Moss, S. A, Bradshaw, J. L, Rinehart, N. J. (2002). Random number generation in autism. Journal of Autism and Developmental Disorders, 32, 43-47.
  • World Medical Association (2004). Declaration of Helsinki. Recuperado de http://www.wma.net/e/policy/b3.htm
  • Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V. Adey, M. B. y Leirer, V. O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of. Psychiatric Research, 17, 37-49.
  • Zec, R F. (1993). Neuropsychological functioning in Alzheimer’s disease. En R. Parks, R F. Zec y R S. Wilson (Eds.), Neuropsychology of Alzheimer’s disease and other dementias. New York: Oxford University Press.
Fuente de los datos: Dialnet