The obestatin/GPR39 systemfrom satellite cell regulation to its applicability in Duchenne muscular dystrophy

  1. González Sánchez, Jessica
Dirigida por:
  1. Jesús Pérez Camiña Director/a
  2. Felipe Casanueva Freijó Director/a
  3. José Luis Relova Quinteiro Director/a

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 04 de abril de 2019

Tribunal:
  1. Amelia Aranega Jiménez Presidenta
  2. Rosalía Gallego Gómez Secretario/a
  3. Eusebio Perdiguero Santamaría Vocal

Tipo: Tesis

Teseo: 587053 DIALNET lock_openMINERVA editor

Resumen

The obestatin/GPR39 system functions as a mediator of skeletal muscle determination, maintenance, and plasticity in physiological and pathological conditions. In satellite cells, the obestatin/GPR39 system acts as an autocrine factor regulating cell cycle progression and fate determination. In Duchenne muscular dystrophy, obestatin signalling addresses multiple pathways needed for phenotypic amelioration, including regulation of myofibre regeneration, activation of the slow oxidative myofibre program, regulation of proteasomal signalling, stabilization of the sarcolemma and induction of corrective autophagy. The results point to the obestatin/GPR39 system as a practical and effective target for future Duchenne muscular dystrophy therapies.